Paper Title :Antiulcer And Enzyme Stability Studies of Synthesised Palmitoylated Derivatives
Author :Asma Saqib, Chandrakant S Karigar
Article Citation :Asma Saqib ,Chandrakant S Karigar ,
(2019 ) " Antiulcer And Enzyme Stability Studies of Synthesised Palmitoylated Derivatives " ,
International Journal of Advances in Science, Engineering and Technology(IJASEAT) ,
pp. 50-54,
Volume-7,Issue-1, Spl. Iss-2
Abstract : The synthesized and completely characterized palmitoylated derivatives PSA PAA, PPAP and N- PPABA were
evaluated for anti ulcer activity and enzyme stability studies. The resultant activity was found to be affected by the type of
NSAID attached to lipid moiety. All the palmitoylated drugs found to be anti ulcerogenic. Salicylic acid with the palmitoyl
moiety was found to be the most labile to hydrolysis. In contrast, the amide prodrugs N- PAA, PPAP and N- PPABA were
the least susceptible to enzymatic and chemical hydrolysis due to presence of amide bond
Key Words - Palmitoylated derivatives, NSAID’s, cyclooxygenase, PSA, PAA, PPAP and N-PPABA
Type : Research paper
Published : Volume-7,Issue-1, Spl. Iss-2
DOIONLINE NO - IJASEAT-IRAJ-DOIONLINE-15336
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Copyright: © Institute of Research and Journals
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Published on 2019-06-18 |
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