Paper Title :Cell Growth Inhibition and Cytotoxicity of 5-Aza-Cytidine on Cisplatin-Resistant Neuroblastoma Cells
Author :Fangyu Peng, Harold C. Simmons
Article Citation :Fangyu Peng ,Harold C. Simmons ,
(2018 ) " Cell Growth Inhibition and Cytotoxicity of 5-Aza-Cytidine on Cisplatin-Resistant Neuroblastoma Cells " ,
International Journal of Advances in Science, Engineering and Technology(IJASEAT) ,
pp. 52-55,
Volume-6, Issue-4, Spl. Iss-2
Abstract : Neuroblastoma (NB) is a malignant tumor of the peripheral sympathetic nervous system in children, accounting
for 8% to 10% of all childhood cancers. Cisplatin is a potent anticancer drug highly cytotoxic to NB cells, but clinical use of
cisplatin for treatment of NB was limited by side effects and acquired cisplatin-resistance of NB cells. To develop new drugs
for treatment of cisplatin-resistant NB, this study aimed to test anticancer activity of 5-Aza-cytidine, a DNA
methyltransferase inhibitor, on cisplatin-resistant NB cells. The experimental results of this study demonstrated cell growth
inhibition and cytotoxicity of 5’-aza-cytidine on cisplatin-resistant NB cells. Moreover, reduced expression of DNMT1 was
detected in the NB cells treated with 5’-aza-cytidine by immunoblot assay. The findings from this study support further
study of 5’-aza-cytidine as a promising drug for treatment of cisplatin-resistant NB in children.
Keywords - Neuroblastoma, 5-Aza-Cytidine, DNA Methyltransferase, 18F-FDG
Type : Research paper
Published : Volume-6, Issue-4, Spl. Iss-2
DOIONLINE NO - IJASEAT-IRAJ-DOIONLINE-14811
View Here
Copyright: © Institute of Research and Journals
| |
 |
| |
 |
PDF |
| |
Viewed - 18 |
| |
Published on 2019-03-21 |
|
