Paper Title :Investigation of Polymorphism and Mutation in the Exon1 Region of MBL2 Gene at Patients with COPD
Author :Negar Aliyari, Bahram Golestani Eimani, Reza Talebi
Article Citation :Negar Aliyari ,Bahram Golestani Eimani ,Reza Talebi ,
(2018 ) " Investigation of Polymorphism and Mutation in the Exon1 Region of MBL2 Gene at Patients with COPD " ,
International Journal of Advances in Science, Engineering and Technology(IJASEAT) ,
pp. 109-112,
Volume-6, Issue-4
Abstract : Introduction and objectives: Obstructive pulmonary disease (COPD) is characterized by chronic airway limitation. The
most common causes of COPD are smoking and respiratory infections. Mannose-binding lectin (MBL) belongs to the family
of collectins and plays a role in the complement activation of the innate immunity through the lectin pathway.
Materials and Methods: In this study, following DNA extraction in 59 patients with COPD, PCR was used to amplify the
exon 1 of MBL2 gene. The PCR products were later sequenced and BLAST search was performed on them. The results were
analyzed using SPSS.
Results: The results of nonparametric statistics showed that there was a significant relationship only between nucleotides
304 deletion mutation (T) of the gene MBL2 exon 1 and there was not a significant correlation between the response to
treatment and remaining polymorphisms and mutations and in the studied subjects.
Keywords – Mannose Binding Lectin (MBL), Chronic Obstructive Pulmonary Disease (COPD), Polymerase Chain
Reaction (PCR), Polymorphism
Type : Research paper
Published : Volume-6, Issue-4
DOIONLINE NO - IJASEAT-IRAJ-DOIONLINE-14287
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Copyright: © Institute of Research and Journals
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Published on 2019-01-31 |
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