Paper Title :Cytotoxic Effects of Caffeic Acid Extracted from Echinaceapurpurea on Human Gastric Cancer Cell Line

Author :F.Moradian, A.Sadeghi, F.Sabouni, F.Sanjarian

Article Citation :F.Moradian ,A.Sadeghi ,F.Sabouni ,F.Sanjarian , (2018 ) " Cytotoxic Effects of Caffeic Acid Extracted from Echinaceapurpurea on Human Gastric Cancer Cell Line " , International Journal of Advances in Science, Engineering and Technology(IJASEAT) , pp. 7-8, Volume-6, Issue-1, Spl. Iss-2

Abstract : Introduction: Echinacea purpurea extract has anticancer and anti-angiogenic properties. The one of component of this plant is caffeic acid is aphenolic compound that has different properties include; antioxidant,anti-inflammatory activity, antivirus, anticancer andimmunomodulatory..Gastric cancer is one of the most common malignant diseases throughout the world, that the prevalence rates show considerable diversity of the world. Objective: In the present study, the toxic effect of caffeic acid extracted from E. purpurea on growth of gastric cancer cell line AGS were investigated. Methods: Different concentarion of caffeic acid 0,2.0 ,2.5 and 3.25mg/ml and standard caffeic acid with 0, 600, 750 and 850 mM/ml treated on AGS cell line at 24 hoursthen cell viability determined using MTT assay. Result: The result obtained from this research showed that the viability percentage after treatment of the plant extract in concentration of 2.0, 2.25 and 3.25 mg/ml and standard caffeic acid in concentration of 600, 750 and 850 mMwere 74.3, 52.6 and 25.6% as well as 81,49,27% , respectively. Conclusion: The results showed that the caffeic acid significantly and dose dependent could reduce the growth of gastric cancer cell line AGS. Keywords - Caffeic acid, Cytotoxic,Echinacea purpurea, Gastric cancer cell line

Type : Research paper

Published : Volume-6, Issue-1, Spl. Iss-2

	|		PDF	|	Viewed - 34	|	Published on 2018-05-14