Paper Title :Expedient Synthesis and Organocatalytic Studies of Enantiomerically Enriched Benzimidazole-Triazoles

Author :Jai V. Sapre, Vaibhav N. Khose, Anil V. Karnik

Article Citation :Jai V. Sapre ,Vaibhav N. Khose ,Anil V. Karnik , (2018 ) " Expedient Synthesis and Organocatalytic Studies of Enantiomerically Enriched Benzimidazole-Triazoles " , International Journal of Advances in Science, Engineering and Technology(IJASEAT) , pp. 42-49, Volume-6, Issue-1

Abstract : Click chemistry induced synthesis of highly enantiomerically enriched 4-(benzimidazolylmethyl)-1,2,3-triazole derivatives 8(a-g) and 9(a-g) has been achieved. These compounds are bestowed with flexibly bound pi-rich hetero-aryl rings, many binding sites and nucleophilic nitrogens in the vicinity of a chiral center. The synthesis is high yielding and regioselective. The synthesized chiral benzimidazole-triazoles have been found useful as the organocatalyst for the enantioselective Diels-Alder (DA) reaction between anthrone (10) and maleimide detivatives 11(a-g). Enantioselectivity levels were found to be dependent on several factors including nature of substituents in benzimidazole-triazoles 8(a-g) and 9(a-g). Index Term- Enantiomerically enriched, click chemistry, tweezer, benzimidazole-triazoles, Diels Alder Adduct

Type : Research paper

Published : Volume-6, Issue-1

	|		PDF	|	Viewed - 46	|	Published on 2018-03-31