Paper Title :Evaluation of Antiviral Property of Cinnamaldehyde-Derived Benzimidazole against Porcine Reproductive and Respiratory Syndrome Virus
Author :Dante Mendillo Fabros Jr., Wasin Charerntantanakul, Wilawun Ruansit, Uthumporn Kankeaw
Article Citation :Dante Mendillo Fabros Jr. ,Wasin Charerntantanakul ,Wilawun Ruansit ,Uthumporn Kankeaw ,
(2017 ) " Evaluation of Antiviral Property of Cinnamaldehyde-Derived Benzimidazole against Porcine Reproductive and Respiratory Syndrome Virus " ,
International Journal of Advances in Science, Engineering and Technology(IJASEAT) ,
pp. 64-66,
Volume-5, Issue-3
Abstract : Porcine reproductive and respiratory syndrome virus (PRRSV) causes an extensive morbidity and fatality of pigs
resulting in significant economic loss of swine industry worldwide .Benzimidazole is n heterocyclic aromatic compound
commonly used as anthelminthics in domestic animals .Its antagonistic properties on various viral and bacterial species have
been widely documented, but the anti-PRRSV property has not yet been elucidated .Therefore,the antiviral effect of
benzimidazole derivative against PRRSV grown in MARC-145 cells was assessed in this study .Benzimidazole was
synthesized from the condensation between1,2-phenylene diamine and cinnamaldehydewhichextracted from the essential oil
of CinnamomumverumJ .Presl.Treatment on pre-infection and post-infection of PRRSVwas evaluated .Results showed that
benzimidazole derivative has little anti-PRRSV property with maximum only 5 %virus titer reduction in pre-virus entry, and
hasno effect in post-infection study .These resultsindicate thatcinnamaldehyde-derived benzimidazole is of limited use for
PRRSV protection.
Index Terms- Cinnamaldehyde, Benzimidazole, Pig, Porcine Reproductive and Respiratory Syndrome Virus
Type : Research paper
Published : Volume-5, Issue-3
DOIONLINE NO - IJASEAT-IRAJ-DOIONLINE-8787
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Published on 2017-09-12 |
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