Paper Title :Evaluation of in Vivo Antioxidant and Lipid Peroxidation Effect of Various Extracts from Whole Plant of Pavetta Indica (Linn) in Rat Fed With High Fat Diet

Author :Abdul Hameed Thayyil, Arumugam Kottai Muthu, Mohammed Ibrahim

Article Citation :Abdul Hameed Thayyil ,Arumugam Kottai Muthu ,Mohammed Ibrahim , (2017 ) " Evaluation of in Vivo Antioxidant and Lipid Peroxidation Effect of Various Extracts from Whole Plant of Pavetta Indica (Linn) in Rat Fed With High Fat Diet " , International Journal of Advances in Science, Engineering and Technology(IJASEAT) , pp. 11-16, Volume-5, Issue-1, Spl. Iss-3

Abstract : The study was carried out to determine the in vivo antioxidant and lipid peroxidation effect of various extracts of aerial parts of Pavetta indica (Linn). in vivo antioxidant and lipid peroxidation activity is screened by inducing hyperlipidemia with the help of High fat diet in wistar albino rats and tissue lipid peroxidation levels TBARS levels of antioxidant Enzymes such as Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx), Glutathione reductase (GR),Glutathione S transferees (GST) and non enzymatic antioxidant Glutathione (GSH). High fat diet rats showed significantly (P<0.001) reduced the levels of tissues enzymatic antioxidant and non enzymatic antioxidant and enhanced the level of TBARS. The level of TBARS are elevated in HFD rats (group II) when compared with control group. Administration of methanolic extract of Pavetta indica in high fat diet rats were showed significantly (p<0.001) increased the levels of antioxidant Enzymes such as Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx), Glutathione reductase (GR),Glutathione S transferees (GST) and non enzymatic antioxidant Glutathione (GSH) when compared with HFD rats (Group II). The methanolic extract of P. indica in high fat diet rats were found lowered the concentration of TBARS when compared with HFD rats (Group II). In comparison of all the three extract treated group with standard group, the methanol extract of Pavetta indica was showed significant result than that of other groups.The methanol extract of Pavetta indica is a significant source of natural antioxidant, which might be helpful in preventing the progress of various oxidative stresses. Key words- Pavetta indica , High fat diet, Lipid peroxidation, Antioxidant.

Type : Research paper

Published : Volume-5, Issue-1, Spl. Iss-3

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