International Journal of Advances in Science, Engineering and Technology(IJASEAT)
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Volume-7,Issue-3  ( Jul, 2019 )
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Sep
Submitted Papers : 80
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  Journal Paper

Paper Title
Mutation Analysis of Cd117 in Hepatocellular Carcinoma

Abstract
The aim of this study was to investigate the presence of activating CD117 gene mutation in hepatocellular carcinoma (HCC). Twenty-two CD117 positive HCC specimens confirmed by immunohisto chemical staining and RT-PCR were analyzed. All specimens were screened for mutations in exons 9 and 11 of the CD117 gene by direct sequencing. No sequence abnormalities were detected. These results suggest that the expression of CD117 tyrosine kinase is independent of mutation in exons 9 and 11 of HCC. Keywords- CD117, Hepatocellular Carcinoma, Receptor Tyrosine Kinase.


Author - Nicholas C. Hsu, Chih-Yuan Chung

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