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Paper Title :
Design, Synthesis And Biological Evolution Of Trimethoxyphenyl Cinnamide Derivatives As Anti-Cancer Agents

Author :Bajee Shaik, Jeevak Sopanrao Kapure, Ahmed Kamal

Article Citation :Bajee Shaik ,Jeevak Sopanrao Kapure ,Ahmed Kamal , (2016 ) " Design, Synthesis And Biological Evolution Of Trimethoxyphenyl Cinnamide Derivatives As Anti-Cancer Agents " , International Journal of Advances in Science, Engineering and Technology(IJASEAT) , pp. 50-52, Volume-4,Issue-2, Spl. Iss-3

Abstract : A series of Phenyl cinnamide derivatives, aminocinnamides (5a-h), N-phenyl ureido benzenecinnamides(PUB- CAs)(6a-h) and phenyl 4-(2-oxoimidazolidin-1-yl)benzenecinnamides derivatives(PIB-CAs) (7a-g)were synthesized and evaluated for their cytotoxicity against selected human cancer cell lines. Conjugate5a displayed potent cytotoxicity with GI50 values of 99 nM against HeLa human cervical cancer cell line which is comparable to the standard 3-methoxy Phenyl cinnamide(1). Molecular docking studies revealed that these conjugate interact and bind more efficiently at colchicine binding site of tubulin. Keywords— Phenyl cinnamide, 2-Chloroethyl urea , Cytotoxicity, Molecular docking.

Type : Research paper

Published : Volume-4,Issue-2, Spl. Iss-3


DOIONLINE NO - IJASEAT-IRAJ-DOIONLINE-4904   View Here

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