Paper Title :In Vivo Fluorescent Imaging Using Cyclic-Arginine -Glycine-Aspartic Acid Peptide And Peg Modified Europium Nanoparticle
Author :Ying Liu
Article Citation :Ying Liu ,
(2015 ) " In Vivo Fluorescent Imaging Using Cyclic-Arginine -Glycine-Aspartic Acid Peptide And Peg Modified Europium Nanoparticle " ,
International Journal of Advances in Science, Engineering and Technology(IJASEAT) ,
pp. 118-124,
Special Issue-5,
Abstract : we report a novel strategy to prepare Eu3+ nanoprobes for in vivo HepG-2 tumor-bearing mice imaging by
conjugation of cyclic-arginine-glycine-aspartic acid peptide (cyclic-RGD) for tumor specific recognition, and PEG to improve
biocompatibility and increase the circulation time. These Eu3+ nanoprobes exhibit excellent luminescent properties, high
dispersion stability in water solutions and no cytotoxicity in living tumor cells after 24 h incubation. The Eu3+ nanoprobes can
be completely cleared after 13 days from liver to feces and not be sequestered in blood and tissues which ensure the security
of the nanoprobes for in vivo applications. The results report here provides a new perspective for the Eu3+ nanoprobes in
biomedical applications.
Index Terms- Nanoparticles; In vivo imaging; tumor specificity; Excretion pathway; Nontoxicity.
Type : Research paper
Published : Special Issue-5,
DOIONLINE NO - IJASEAT-IRAJ-DOIONLINE-3627
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Copyright: © Institute of Research and Journals
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Published on 2016-01-05 |
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