International Journal of Advances in Science, Engineering and Technology(IJASEAT)
.
Follow Us On :
current issues
Volume-9,Issue-3  ( Jul, 2021 )
Statistics report
Dec
Submitted Papers : 80
Accepted Papers : 10
Rejected Papers : 70
Acc. Perc : 12%
  Journal Paper


Paper Title :
Synthesis Of Spiro Barbiturates Triones And Glycosides

Author :P. K. Gaidhane, M. K. Gaidhane, S. K. Kharkate

Article Citation :P. K. Gaidhane ,M. K. Gaidhane ,S. K. Kharkate , (2015 ) " Synthesis Of Spiro Barbiturates Triones And Glycosides " , International Journal of Advances in Science, Engineering and Technology(IJASEAT) , pp. 1-10, Special Issue-1

Abstract : Malonic acid undergoes condensation readily with ureas to yield barbituric acids 2 which on bromination give 5,5-dibromobarbituric acids 3. Reaction of glycerol with these 5,5-dibromo barbituric acids afforded 3-Hydroxymethyl-1,4-dioxo-7,9-diaza-/ 7- aryl-7,9-diaza-/ 7,9-diaryl-7,9-diaza-spiro[4,5]deca- 6,8,10-triones 4 which are on glucosylation gives 3- O-β-D-glucopyranosyl-oxy-methyl-1,4-dioxo-7,9- diaza-/7-aryl-7,9-diaza-/7,9-diaryl-7,9-diaza- spiro[4,5]deca-6, 8,10-triones 6. The structures of the products have been assigned on the basis of 1 H NMR, 13 C NMR, FAB-MS, optical activity and elemental analysis. The title compounds are found to have antibacterial and antifungal activities. Key words: Barbituric acid, 5, 5-dibromo barbituric acid, , dioxolane, triones, glucosides

Type : Research paper

Published : Special Issue-1


DOIONLINE NO - IJASEAT-IRAJ-DOIONLINE-2417   View Here

Copyright: © Institute of Research and Journals

| PDF |
Viewed - 91
| Published on 2015-06-19
   
   
IRAJ Other Journals
IJASEAT updates
Volume-9,Issue-2(April, 2020)
The Conference World

JOURNAL SUPPORTED BY