International Journal of Advances in Science, Engineering and Technology(IJASEAT)
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Volume-8,Issue-1  ( Jan, 2020 )
Statistics report
Jun
Submitted Papers : 80
Accepted Papers : 10
Rejected Papers : 70
Acc. Perc : 12%
  Journal Paper

Paper Title
Semi-Quantitative Analysis of Nitric Oxide Production in Three-dimensional Glioblastoma Multiforme Models in Vitro

Abstract
Glioblastoma Multiforme (GBM) remains an incurable brain disease. One of the most important signaling molecules in the brain, nitric oxide (NO) mediates important inter- and intracellular interaction in astrocytes and neurons. In the presented study, the three-dimensional glioblastoma multicellular models were established from A-172 cells and grown in vitro in a picowell array. "Intra-spheroid" NO content and its association with mitochondrial function were studied at a resolution of single 3D object. The association between "intra-spheroid" levels of nitric oxide and mitochondrial status is revealed in real-time measurements and may serve as a significant target for tumor cure. Keywords - Glioblastoma Multiforme, Nitric Oxide, Mitochondrial Membrane Potential, Three-Dimensional Multicellular Models in Vitro


Author - Elena Afrimzon, Yana Shafran, Naomi Zurgil, Maria Sobolev, Mordechai Deutsch

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