International Journal of Advances in Science, Engineering and Technology(IJASEAT)
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current issues
Volume-7,Issue-3  ( Jul, 2019 )
Statistics report
Sep
Submitted Papers : 80
Accepted Papers : 10
Rejected Papers : 70
Acc. Perc : 12%
  Journal Paper

Paper Title
Investigation of Polymorphism and Mutation in the Exon1 Region of MBL2 Gene at Patients with COPD

Abstract
Introduction and objectives: Obstructive pulmonary disease (COPD) is characterized by chronic airway limitation. The most common causes of COPD are smoking and respiratory infections. Mannose-binding lectin (MBL) belongs to the family of collectins and plays a role in the complement activation of the innate immunity through the lectin pathway. Materials and Methods: In this study, following DNA extraction in 59 patients with COPD, PCR was used to amplify the exon 1 of MBL2 gene. The PCR products were later sequenced and BLAST search was performed on them. The results were analyzed using SPSS. Results: The results of nonparametric statistics showed that there was a significant relationship only between nucleotides 304 deletion mutation (T) of the gene MBL2 exon 1 and there was not a significant correlation between the response to treatment and remaining polymorphisms and mutations and in the studied subjects. Keywords – Mannose Binding Lectin (MBL), Chronic Obstructive Pulmonary Disease (COPD), Polymerase Chain Reaction (PCR), Polymorphism


Author - Negar Aliyari, Bahram Golestani Eimani, Reza Talebi

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| Published on 2019-01-31
   
   
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