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Paper Title :
Pharmacological Evaluation of 2-(Phenyl Hydrazino Methyl) Quinazolin-4(3h)-One for Anticancer Activity Focussed on Anti-Parp Activity

Author :Anchitha Teresa George, Winson Sam

Article Citation :Anchitha Teresa George ,Winson Sam , (2018 ) " Pharmacological Evaluation of 2-(Phenyl Hydrazino Methyl) Quinazolin-4(3h)-One for Anticancer Activity Focussed on Anti-Parp Activity " , International Journal of Advances in Science, Engineering and Technology(IJASEAT) , pp. 43-49, Volume-6, Issue-4

Abstract : Poly (ADP-ribosyl) polymerases (PARPs) are enzymes that catalyze the synthesis of the biopolymer Poly (ADPribose) (PAR), a post translational modification that plays an important role in genomic repair, gene transcription, energy metabolism, cell signalling etc.2-(phenyl hydrazino methyl) quinazolin-4(3H)-one, being NAD+ mimetics can act as PARP inhibitors, hence can be used as an anticancer drug. The compound is evaluated for its antiPARP activity and it showed significant anticancer property. Keywords - PARP, ARTD,PARsylation,NAD+, BRCA mutations, 4(3H)-Quinazolinone,SAR,PASSonline,2-(phenyl hydrazino methyl) quinazolin-4(3H)-one, antiPARP activity. In silico, docking

Type : Research paper

Published : Volume-6, Issue-4


DOIONLINE NO - IJASEAT-IRAJ-DOIONLINE-13933   View Here

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