International Journal of Advances in Science, Engineering and Technology(IJASEAT)
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current issues
Volume-7,Issue-3  ( Jul, 2019 )
Statistics report
Nov
Submitted Papers : 80
Accepted Papers : 10
Rejected Papers : 70
Acc. Perc : 12%
  Journal Paper

Paper Title
Pharmacological Evaluation of 2-(Phenyl Hydrazino Methyl) Quinazolin-4(3h)-One for Anticancer Activity Focussed on Anti-Parp Activity

Abstract
Poly (ADP-ribosyl) polymerases (PARPs) are enzymes that catalyze the synthesis of the biopolymer Poly (ADPribose) (PAR), a post translational modification that plays an important role in genomic repair, gene transcription, energy metabolism, cell signalling etc.2-(phenyl hydrazino methyl) quinazolin-4(3H)-one, being NAD+ mimetics can act as PARP inhibitors, hence can be used as an anticancer drug. The compound is evaluated for its antiPARP activity and it showed significant anticancer property. Keywords - PARP, ARTD,PARsylation,NAD+, BRCA mutations, 4(3H)-Quinazolinone,SAR,PASSonline,2-(phenyl hydrazino methyl) quinazolin-4(3H)-one, antiPARP activity. In silico, docking


Author - Anchitha Teresa George, Winson Sam

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| Published on 2018-12-26
   
   
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