Paper Title :Cytotoxic Effects of Caffeic Acid Extracted from Echinaceapurpurea on Human Gastric Cancer Cell Line
Author :F.Moradian, A.Sadeghi, F.Sabouni, F.Sanjarian
Article Citation :F.Moradian ,A.Sadeghi ,F.Sabouni ,F.Sanjarian ,
(2018 ) " Cytotoxic Effects of Caffeic Acid Extracted from Echinaceapurpurea on Human Gastric Cancer Cell Line " ,
International Journal of Advances in Science, Engineering and Technology(IJASEAT) ,
pp. 7-8,
Volume-6, Issue-1, Spl. Iss-2
Abstract : Introduction: Echinacea purpurea extract has anticancer and anti-angiogenic properties. The one of component of
this plant is caffeic acid is aphenolic compound that has different properties include; antioxidant,anti-inflammatory activity,
antivirus, anticancer andimmunomodulatory..Gastric cancer is one of the most common malignant diseases throughout the
world, that the prevalence rates show considerable diversity of the world.
Objective: In the present study, the toxic effect of caffeic acid extracted from E. purpurea on growth of gastric cancer cell
line AGS were investigated.
Methods: Different concentarion of caffeic acid 0,2.0 ,2.5 and 3.25mg/ml and standard caffeic acid with 0, 600, 750 and 850
mM/ml treated on AGS cell line at 24 hoursthen cell viability determined using MTT assay.
Result: The result obtained from this research showed that the viability percentage after treatment of the plant extract in
concentration of 2.0, 2.25 and 3.25 mg/ml and standard caffeic acid in concentration of 600, 750 and 850 mMwere 74.3,
52.6 and 25.6% as well as 81,49,27% , respectively.
Conclusion: The results showed that the caffeic acid significantly and dose dependent could reduce the growth of gastric
cancer cell line AGS.
Keywords - Caffeic acid, Cytotoxic,Echinacea purpurea, Gastric cancer cell line
Type : Research paper
Published : Volume-6, Issue-1, Spl. Iss-2
Copyright: © Institute of Research and Journals
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Published on 2018-05-14 |
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