International Journal of Advances in Science, Engineering and Technology(IJASEAT)
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Volume-7,Issue-2, Spl. Iss-2  ( Jun, 2019 )
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Aug
Submitted Papers : 80
Accepted Papers : 10
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Acc. Perc : 12%
  Journal Paper

Paper Title
Expedient Synthesis and Organocatalytic Studies of Enantiomerically Enriched Benzimidazole-Triazoles

Abstract
Click chemistry induced synthesis of highly enantiomerically enriched 4-(benzimidazolylmethyl)-1,2,3-triazole derivatives 8(a-g) and 9(a-g) has been achieved. These compounds are bestowed with flexibly bound pi-rich hetero-aryl rings, many binding sites and nucleophilic nitrogens in the vicinity of a chiral center. The synthesis is high yielding and regioselective. The synthesized chiral benzimidazole-triazoles have been found useful as the organocatalyst for the enantioselective Diels-Alder (DA) reaction between anthrone (10) and maleimide detivatives 11(a-g). Enantioselectivity levels were found to be dependent on several factors including nature of substituents in benzimidazole-triazoles 8(a-g) and 9(a-g). Index Term- Enantiomerically enriched, click chemistry, tweezer, benzimidazole-triazoles, Diels Alder Adduct


Author - Jai V. Sapre, Vaibhav N. Khose, Anil V. Karnik

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