Paper Title :Combined Extract of Zizyphi Semen and Codonopsis Radix improves Synaptic Deficits and Memory Impairments in an amyloid β-induced Dementia Moue Model

Author :Huiyoung Kwon, In Ho Jung, Kyoung Sook Kim, Jong Hoon Ryu, Dong Hyun Kim

Article Citation :Huiyoung Kwon ,In Ho Jung ,Kyoung Sook Kim ,Jong Hoon Ryu ,Dong Hyun Kim , (2017 ) " Combined Extract of Zizyphi Semen and Codonopsis Radix improves Synaptic Deficits and Memory Impairments in an amyloid β-induced Dementia Moue Model " , International Journal of Advances in Science, Engineering and Technology(IJASEAT) , pp. 39-43, Volume-5, Issue-4, Spl. Iss-2

Abstract : Amyloid β (Aβ), a protein found in senile, is a major hallmark of Alzheimer’s disease (AD). Since Aβ causes many pathological events within the AD brain, a therapeutic target for AD is the prevention of Aβ toxicity. In the present study, we tested whether a combined extract of Zizyphi Semen and Codonopsis Radix (ZSCR) prevented Aβ-induced aberrant synaptic plasticity and memory impairments. In Aβ-induced LTP deficit experiments, ZSCR ameliorated Aβ- induced LTP deficit in a concentration-dependent manner (P< 0.05). ZSCR also ameliorated object recognition and passive avoidance memory impairments induced by Aβ. These results suggest that ZSCR may be a good candidate for preventing and ameliorating memory deficits in patients with AD. Keywords - Amyloid β (Aβ), Codonopsis Radix, Long-term potentiation (LTP), Memory.Zizyphi Semen.

Type : Research paper

Published : Volume-5, Issue-4, Spl. Iss-2

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