Paper Title
Evaluation of Antiviral Property of Cinnamaldehyde-Derived Benzimidazole against Porcine Reproductive and Respiratory Syndrome Virus

Porcine reproductive and respiratory syndrome virus (PRRSV) causes an extensive morbidity and fatality of pigs resulting in significant economic loss of swine industry worldwide .Benzimidazole is n heterocyclic aromatic compound commonly used as anthelminthics in domestic animals .Its antagonistic properties on various viral and bacterial species have been widely documented, but the anti-PRRSV property has not yet been elucidated .Therefore,the antiviral effect of benzimidazole derivative against PRRSV grown in MARC-145 cells was assessed in this study .Benzimidazole was synthesized from the condensation between1,2-phenylene diamine and cinnamaldehydewhichextracted from the essential oil of CinnamomumverumJ .Presl.Treatment on pre-infection and post-infection of PRRSVwas evaluated .Results showed that benzimidazole derivative has little anti-PRRSV property with maximum only 5 %virus titer reduction in pre-virus entry, and hasno effect in post-infection study .These resultsindicate thatcinnamaldehyde-derived benzimidazole is of limited use for PRRSV protection. Index Terms- Cinnamaldehyde, Benzimidazole, Pig, Porcine Reproductive and Respiratory Syndrome Virus