Green Biosynthesis of Silver Nanoparticles Conjugated to Gefitinib as Delivery Vehicle
Green synthesized silver nanoparticles (AgNPs) were extracted from Aerva javanica plant using eco-friendly
green chemistry approach. Anti-cancer drug gefitinib conjugated to these spherical shaped with an average size of 5.7nm
AgNPs. Gefitinib-conjugated AgNPs were characterized by ultraviolet–visible spectroscopy, fourier transform-infrared (FTIR)
and scanning transmission electron microscopy (STEM) analysis. These results were confirmed the conjugation of
gefitinib with AgNPs at 490nm wavelength. The effect of acidic pH 4.5 showed the agglomerate formation of gefitinib in
significant amount in a shorter period which delivers drugs effectively in a tumor cells. The cell viability was analysed in
human breast cancer cell line (MCF-7) determined that gefitinib-AgNPs were 50% more effective than gefitinib alone. It was
concluded that the gefitinib conjugated AgNPs are used as effective delivery vehicle which are less toxic in nature.
Keywords- Silver nanoparticles, Aerva javanica, Gefitinib, Breast cancer.