Impress of Betatrophin in the Treatment of Mice with Diabetes Type 1
Betatrophin is a secreted protein of 198 amino acids that promotes β cell proliferation.
It is expressed in the liver and in white and brown adipose tissue of mice. In humans, betatrophin is expressed in the liver.
Evaluation ofbetatrophin as alternative treatment instead of insulin injection in mice with type1 diabetes.
Material and Methods:
This experimental study was based on 30mice, the study was carried out at animal house,college of medicine-University of
Baghdad. These rats were provided from the animal house of medicine, pharmacology Colleges-University of Baghdad.
These mice were divided into three groups firstgroup were mice treated with insulin (10 mice), second group were mice
treated with betatrophin (10 mice) and third group consider as a control group non-diabetic mice (10 mice).
Plasma mice C-peptide concentration were measured using an enzyme-linked immunosorbent assay. Fasting blood glucose
was measured by using colorimetric methods, these measurements was done in the Teaching laboratories of Baghdad
Level of fasting blood glucose show no significant differences amonginducible type1 diabetic(T1DM) mice treated with
insulin, inducible type1 diabetic(T1DM) mice treated with betatrophin and their control group (90.0 ± 10.8 ,75 ±12.9,85
±17) mg/dl with p=0.016.
that inducible type1 diabetic(T1DM) mice with betatrophin inj. treatment had higher significant mean of c-peptide (3.3±
2.2ng/ml) than inducible type1 diabetic(T1DM) mice with insulin inj. Treatment (2.9 ±0.8 ng/ml) but both groups had
significant lower mean than control non-diabetic mice (5.3 ±1.2ng/ml).
level of blood glucose had positive significant correlation with c-peptide (r=0.45, p=0.01)
Data suggested that betatrophin is lower blood sugar and might be lower the dependence of diabetic patients on insulin
injection treatment, but this study need for further work to say that betatrophin can replace the insulin treatment.