Paper Title
Is a Refined Vegetable Oils a Risk Factor for Recurrence of Coronary Artery Diseases and Hypercholesterolemia? A Retrospective Cohort Study on 107 Patients

Introduction: InIndia, the heart diseases like coronary artery diseases (CAD) and hypercholesterolemia (HC) are the main causes of death. The refined vegetable oilsare consumed regularly in diet; especially in rural part of India. Aim: This study mainly purpose to verify the effect of the refined vegetable oils on recurrence of coronary artery disease (CAD) and hypercholesterolemia (HC). Materials and methods: The retrospective cohort study was conducted on 140 sequential patients admitted and diagnosed with CAD and HC in a rural medical institute in Udaipur, Rajasthan, India.The complete medical case files were examined through the study investigators and relative findings were noted. The patient’s exposure to the refined vegetable oils were assessed via questioning; so asthey mainly divided in two groups as ‘exposed group’, those who were continued the refined vegetable oils consumption and ‘non-exposed group’, those were who stopped along with 6 month follow up for evaluation of recurrence of CAD and HC scheduled. CAD recurrence and HC recurrence were considered as the outcomes. The effect of the refined vegetable oils on recurrence of CAD and HC were investigated according to a logistic regression model. Results: Total107 patients were fulfilled inclusion criteria; 63 patients were in ‘exposed group’. The 6-month follow up results were the refined vegetable oils consumption a 34.93 times the odds of hypercholesterolemia recurrence (P = 0.017; 95% CI for OR ranged from 1.90 to 643.46), while 26.60 times the odds of coronary artery diseases recurrence (P = 0.003; 95% CI for OR ranged from 3.04 to 232.62) in exposed and non-exposed group which were statistically significance difference found. Conclusion: The refined vegetable oils consuming patients were tends to increase the risk of recurrence of coronary artery disease and hypercholesterolemia. Conflict-of-interest statements: All authors hereby declare that they have no ‘conflict-of-interest’. Fundings: This study was fully self-funded by the authors. Keywords - Cohort study, Coronary artery diseases, Hypercholesterolemia, Refined vegetable oil, Trans fat. Abbreviations - CAD-coronary artery disease, HC-hypercholesterolemia, TC Level- total cholesterol level, HDL - high density lipoprotein, LDL - low density lipoprotein.