Study Mechanism Antidiabetic Extract Cemba Leaf (Acacia Rugata (Lam.) Fawc. Rendle) Through Α-Glucosidase Enzyme Inhibition
Diabetes is the world's oldest diseases, diabetes is associated with the metabolism of glucose in the blood.
Medically, the notion of diabetes mellitus aspect extends to a series of symptoms that arise in a person caused by an increase
in blood sugar levels (hyperglycemia) due to lack of insulin. The development of diabetes mellitus treatment has been done,
one of them is the use of natural materials and the development of traditional medicine that is more minimal side effects as
antidiabetic drugs through the mechanism of inhibition of α-glucosidase enzyme and antioxidant (DPPH radical reduction).
One of the local plants (endemic) that can be developed as an antidiabetic drug candidate is Cemba plants (Acacia rugata
(Lam.) Fawc. Rendle).
Cemba (Acacia rugata (Lam.) Fawc. Rendle) one of the rare and endemic plants in South Sulawesi precisely in Enrekang.
Community Enrekang leaves Cemba (Acacia rugata (Lam.) Fawc. Rendle) is used as an herb that is also believed to
neutralize the fat from the meat so it does not cause hypertension and cholesterol, so that the potential of this plant is very
large for the treatment of hypertension or hyperglycemia (diabetes mellitus), This research is expected to help determine the
biological activity of methanol extract of leaves Cemba (Acacia rugata (Lam.) Fawc. Rendle) as an antidiabetic and the
mechanism through inhibition of α-glucosidase enzymes and antioxidants.
Keywords - Acacia rugata (Lam.) Fawc. Rendle, Diabetes mellitus, enzyme α-glucosidase, DPPH, hyperglycemia .