Novel Multifunctional Nanoparticles for Efficient Bioseparation of Cells in Microfluidic Systems
New hybrid nanoparticles based on gold decorated magnetic core, embedded into silica matrix were prepared.
Functionalization of the particles was made with folic acid as model bioligand for cellular targeting. The multifunctional
NPs were characterized from the point of view of size, surface potential and optical properties. The morphology of the
hybrid nanoparticles was investigated by TEM imaging. Folic acid attachment was confirmed by zeta potential and FTIR
spectra. The particles obtained were spherical, rather monodisperse and stable in aqueous solution up to 4 week of storage at
room temperature. The shell of silica deposited on hybrid Fe3O4@Au nanoparticles confers a better biocompatibility and
reduce toxicity, compared with magnetic and metallic component.The silica-coated multifunctional NPs appear to be
promising nanomaterials with potential for cell separation in microfluidic devices.