Design and Characterization of Bio-Nanocomposites For 5-Fluorouracil Drug Delivery and Antimicrobial Study
In the present study, clay loaded-bio-nanocomposite films (BNCFs) were used (as a drug carrier) as a delivery
systems for an anticancer drug. Polyvinyl alcohol (PVA) and chitosan (CS) were solution-blended with different wt% (1 to
5wt%) of Ca
MMT via solution casting technique. 2% glutaraldehyde, as a crosslinking agent was added to the blended
solution. An anticancer drug, 5-flurouracil (5-FU) was loaded into nanoclay loaded CS-PVA BNCFs for the in-vitro drug
delivery studies. The morphology and structure of BNCFs were characterized by X-ray diffraction (XRD), fourier transform
infra-red spectroscopy (FTIR), transmission electrom microscopy (TEM), scanning electron microscopy (SEM) and
thermogravemetric analysis (TGA). The selling capacity and 5-FU drug release from BNCFs was analysed at different time
intervals. The antibacterial activity of the CS-PVA/Ca
MMT composites showed a significant effect against salmonella and
staphylococcus aureus, whereas 5-Fu encapsulated nanoclay loaded CS-PVA BNCFs not showed any toxicity. Thus, the
present study, noticeably, suggests new antibacterial materials, which may potentially be usefull for wound and burns
dressing and also as antibacterial packaging materials.
Index terms- 5-Fluorouracil, Chitosan, Polyvinyl alcohol, nanoclay, Salmonella, Staphylococcus aureus.