Cytotoxicity Effects of Nanonaringin on Nalm6 Cell Line
Acute Lymphoblastic Leukemia(ALL) a malignant disorder with T or B is the source of lymphocyte precursors.
The disease is more prevalent in children but it can occur at any age. The identification of new cytotoxic drug with low sid
effects on immune system has developed as important area in new studies of immunopharmacology.Naringinis a natural
flavonoids in citrus fruits such with anti-oxidative and anti-cancer properties. Its therapeutic potential is substantially
hindered by the rather low water solubility and bioavailability, hence the need for suitable carriers. In this report we
employed nanogel-based nanoparticle approach to improve upon its effectiveness.Myristic acid-chitosan (nanogels were
prepared by the technique of self-assembly. Naringinwas loaded into the nanogels. Cytotoxicity and viability of
nanonaringin were assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and dye exclusion
assay. Proliferation of nalm6 cells was significantly inhibited by nanonaringin in a concentration-dependent manner in
defined times..The high drug-targeting potential and efficiency demonstrates the significant role of the anticancer properties
of Naringin -loaded nanoparticles.
Keywords- Anticancer activity, Naringin,Nanonaringin, MTT assay, Human breast adenocarcinoma