Antibacterial And Antityrosinase Activities Of Isolated Compounds From Stem Bark Of Ficus Platyphylla Del
An investigation of the chemical constituents into the stem bark of Ficus platyphylla (Moraceae) has resulted in
the isolation of hordenine, epicatechin, lupeol, lupeol acetate and α-amyrin acetate. Their structures were determined using
spectroscopic data as well as comparison with literature data. The antibacterial assay has been tested against Gram positive
and Gram negative bacteria, while the tyrosinase inhibition assay was examined using L-Dopa as a substrate of mushroom
tyrosinase enzyme. Hordenine, epicatechin, lupeol, lupeol acetate and α-amyrin acetate showed minimum inhibition
concentration (MIC) values in the range of 225-900 μg/mL against the bacterial strains. Lupeol, lupeol acetate and α-amyrin
acetate showed significant antityrosinase activity against mushroom tyrosinase enzyme with percent inhibition of 67.7%,
66.2% and 62.2%, respectively.
Keywords— Antibacterial, antityrosinase, chemical constituents, Ficus platyphylla.