Acute And Subchronic Toxicity Investigation of New Doped Nanocrystallized Materials
Nanoparticles are widely used for hydroxyapatite materials. Toxicity analysis are carried out to evaluate the
safety of modified nanoparticles. The toxicological behavior of new doped nanocrystallized hydroxyapatite was studied in
vivo in rats and mice. Acute and subchronic studies were carried out. Biochemical and hematological analysis were also
done. There was a small change in alanine-aminotransferase (ALT) level at a high dosage. The results indicate a safe
Keywords— Doped Nanocrystallized Hydroxyapatite, Acute and Subchronictoxicology, Laboratoryanimals, Hematological
and Biochemical Indexes.