Paper Title
Acute And Subchronic Toxicity Investigation of New Doped Nanocrystallized Materials

Nanoparticles are widely used for hydroxyapatite materials. Toxicity analysis are carried out to evaluate the safety of modified nanoparticles. The toxicological behavior of new doped nanocrystallized hydroxyapatite was studied in vivo in rats and mice. Acute and subchronic studies were carried out. Biochemical and hematological analysis were also done. There was a small change in alanine-aminotransferase (ALT) level at a high dosage. The results indicate a safe toxicological profile. Keywords— Doped Nanocrystallized Hydroxyapatite, Acute and Subchronictoxicology, Laboratoryanimals, Hematological and Biochemical Indexes.