Research And Biological Testing Of 99mtc-Labeled Fluoroquinolones
The researches of creation of specified reagent for production of 99mTc-labeled fluoroquinolones were carried out.
Evaluation of the reaction mixture components influence on the radiochemical purity of the produced pharmaceuticals was
performed using thin layer chromatography. Functional applicability of the labeled antibiotics for diagnostics of
inflammatory process was shown on experimental animals (rats) with different localization inflammation model. The
toxicity degree of the produced radiochemical pharmaceuticals was evaluated, pharmacokinetics was studied, and expiration
date and shelf-life were settled.
Keywords- Radiochemical Pharmaceutical, Ciprofloxacin Hydrochloride (CF), Norfloxacin Hydrochloride (NF), Bacterial