Paper Title
Correlation Between Serum Lactate Dehydrogenase (LDH) And Seizure – An Observation In Clinical Cases

Introduction Serum lactate dehydrogenase (LDH) is an enzyme that catalyses the interconversion of lactate and pyruvate. LDH inhibition can reduce the excitability of neurons in mice; this leads to the hope that LDH inhibitor may be used to treat seizure. Translating this laboratory experimental finding to clinical medicine, one would like to investigate the potential correlation of serum LDH and seizure in human. Objective The objective of this study is to investigate “would a patient with an acute illness, who has seizure as one of the clinical manifestations, has an elevated serum LDH before, during, or after an episode of seizure?” Method The PubMed database was searched. The search algorithm was: (epileps* OR seizur*) AND (lactate dehydrogenase* OR LDH). Patients with known established conditions that could elevate LDH were excluded. Results Fifteen clinical cases met the criteria and were reviewed. Their serum LDH levels in relation to a seizure event were studied. The ratio of serum LDH to the upper limit of the reference ranges were all above 1.0 (ranging from 1.4 to 23.1). Conclusion Patients with an acute illness, who had seizure as one of their clinical manifestations, had elevated serum LDH above the upper limit, before, during, or after an episode of seizure.