Titania Supported Nickel Catalyst For Hydrogenation Of Artemisinin To Deoxyartemisinin
Titania supported nickel catalyst (Ni-TiO2)was synthesized by impregnation of Ni(NO3)2.6H2O on a titania
prepared from titanium iso-propoxide by a sol-gel techniqueusing cetyltrimethyl ammonium chloride as atemplating agent.
The catalyst was characterized by powder X-ray diffraction, BET surface area analysis, and surface acidity measurement
viaadsorption of organic base pyridine. The addition of nickelontitania increased the physical and chemical properties of the
catalyst, i.e. crystalinity, surface area and surface acidity. The synthesized Ni-TiO2catalyst was applied for the hydrogenation
of the artemisininto deoxyartemisinin giving yields up to34% in mild reaction conditions.
Keywords- Artemisinin, Deoxyartemisinin, Nickel Catalyst, Titania, Sol-Gel Technique