Green Approach Towards The Synthesis Of 1-Phenyl Naphthalene Lignan And Their Derivatives
-The use of green chemistry technique
reduces the chemical waste and reaction time.
Recently, it has been proved in several organic
synthesis and chemical transformation. In present
work, synthesis of 1-phenyl naphthalene fromβ-
Benzoyl propionic acid, aryl aldehyde, acetic
anhydride and pyridine was carried out and it was
cyclised with PPA and sulphamic acid, by using
microwave irradiation. It is a three step reaction. In
first step synthesis of α-arylidineγ-phenyl δ,β-
butenolide by perkin reaction, in second step
synthesis of α-arylidine, β-BenzoylPropionic acid by
cleavage using alcoholic sodium carbonate and In
third step synthesis of 1-phenyl naphthalene by
cyclisation using PPA , H2SO4, Sulphamic acid has
been carried out. It has been observed that microwave
irradiation method produces better yield and reduces
the time period compared with conventional method.
The structure of 1-phenyl naphthalene was confirmed
by spectral and elemental analysis.
Keywords:Microwave irradiation, 1-phenyl
naphthalene, PPA, cyclisation, green chemistry