Investigation of Novel Chrysin-Cyclodextrin Complexes Efficiency Against Liver Disease
Chrysin (5,7-dihydroxyflavone) shows anti-inflammatory, antioxidant, anti-cancer, anti-allergic and
hepatoprotective properties, therefore it could be an efficient agent against hepatic pathological states, such as liver fibrosis.
However, chrysin is poorly soluble in water and has a low bioavailability, thus it needs to be complexed with carriers such as
cyclodextrins in order to become bioavailable and to exert its effect. In this study, original chrysin-cyclodextrin complexes
were synthesized and tested for biocompatibility against cells from Huh7 cell line. The purpose of the present study was to
synthesize, characterize, and validate in vitro a new drug delivery system designed to investigate chrysin’s effect on liver
disease. Chrysin-RAMEB and Chrysin-HPBCD complexes proved to increase chrysin solubility and to deliver this flavonoid
properly to the cells, also displaying the highest biocompatibility.
Keywords - Chrysin; cyclodextrins; RAMEB; HPBCD; liver fibrosis; drug delivery.