Cytotoxic Effects of Caffeic Acid Extracted from Echinaceapurpureaon Human Gastric Cancer Cell Line
Introduction: Echinacea purpurea extract has anticancer and anti-angiogenic properties. The one of component of this plant
is caffeic acid is aphenolic compound that has different properties include; antioxidant,anti-inflammatory activity, antivirus,
anticancer and immunomodulatory.. Gastric cancer is one of the most common malignant diseases throughout the world, that
the prevalence rates show considerable diversity of the world.
Objective: In the present study, the toxic effect of caffeic acid extracted from E. purpureaon growth of gastric cancer cell
line AGS were investigated.
Methods: Different concentarion of caffeic acid 0,2.0 ,2.5 and 3.25mg/ml and standard caffeic acid with 0, 600, 750 and 850
mM/ml treated on AGS cell line at 24 hours then cell viability determined using MTT assay.
Result: The result obtained from this research showed that the viability percentage after treatment of the plant extract in
concentration of 2.0, 2.25 and 3.25 mg/ml and standard caffeic acid in concentration of 600, 750 and 850 mMwere 74.3,
52.6 and 25.6% as well as 81,49,27% , respectively.
Conclusion: The results showed that the caffeic acid significantly and dose dependent could reduce the growth of gastric
cancer cell line AGS.
Keywords - Caffeic acid, Cytotoxic, Echinacea purpurea, Gastric cancer cell line