Synthesis and Biological Evaluation of Schiff Base Derivatives of Furfural based Heterocyclic Flavones
Synthesized a total of twelve new furfural flavone Schiff base derivatives starting from commercially available
phloroglucinol. In the first stage the corresponding acetophenone key intermediate was synthesized from the starting material
and was condensed with furfural followed by cyclisation, and formylation. Finally, the formylated flavone was condensed with
various aromatic primary amines to obtain the desired Schiff base derivatives. All the synthesized furfural flavone Schiff base
derivatives were tested for their anticancer and antibacterial activities and the results were analysed in the light of their
Index Terms - Furfuralflavone, Aromatic Amines, Schiff Bases, Antibacterial Activity.