Medium Composition Effect on Coenzyme Q Production by Metabolic Engineered Escherichia Coli Strains
Coenzyme Q (CoQ) applications have increased significantly in the past few years. Then, there is a strong interest
in developing better production systems and processes. In the present work, the use of metabolically modified Escherichia coli
was evaluated using different culture media for the accumulation of CoQ. The results showed that glycerol and succinate
significantly increased CoQ accumulation in the control and modified E. coli strains in comparison to glucose, with glycerol
showing the highest productivity in both strains.
Index Terms - coenzyme Q, Escherichia coli, metabolic engineering, ubiquinone