In Vitro Effect of Statins on the Actin Cytoskeleton and Cell Cycle of Pankreatic Cancer Cells
Statins represent a major class of compounds for the treatment of hypercholesterolemia due to their ability to
inhibit de novo cholesterol synthesis, namely mevalonate pathway. In recent years, the functions of statins unrelated to
mevalonate pathway are becoming interesting subject of research mainly because of their so called pleiotropic effects, that
include the possible anti-oxidative effects, anti-inflammatory and immunomodulary functions, modulation of cell
proliferation and endothelial function or even canceroprotective effect. Thanks to the potentional canceroprotective effects of
statins their application as chemoadjuvants has been proposed. For this application the exact molecular mechanisms of
statins' actions should be elucidated. Our study is focused on the effect of the all commertially available statins on cell
morphology, cytoskeleton and cell cycle of pancreatic cancer cells.
Keywords - Statins, pancreatic cancer, cell cycle.