Paper Title
Relationship between Protein Carbonylation and Type-2 Diabetes Mellitus in Kolkata, India

Diabetes mellitus is a group of metabolic disorders that is characterized by hyperglycemia. Hyperglycemia occurs mainly due to the defects in insulin secretion, insulin action or both. It is accelerated by poor glycemic control which increases free radicals causing oxidative stress. A total 360 subjects were involved in the study. The cases comprised of 90 each of male female diabetics. 90 non diabetics males and 90 non diabetic females were chosen as controls. Protein carbonylation in T2DM (Type 2 diabetes mellitus) patients was estimated by DNPH method. The mean and sd values of PC (protein carbonyl) were calculated for all cases and control of both sexes of three different age groups. Both diabetic males and females had higher PC level as compared to controls (p value 0.05). The present study shows that with increase in free radicals in T2DM causes oxidation of protein which in term increases a level of PC.