Metronomic Chemotherapy: Changing the Approach that Bigger is always Better
Conventional chemotherapy and even new drug delivery systems lead to adverse drug reactions that restrict
dosing and interferes the efficacy of antineoplastic drugs. So exploring new therapeutic targets as well as new therapeutic
strategies are essential to improve cancer treatment. Metronomic chemotherapy is one such new modality of administering
cytotoxic drugs. Metronomic chemotherapy involves frequent administration of conventional chemotherapeutic agents at
very low doses to target activated endothelial cells in tumors without any drug free break. In addition to reduced acute
toxicity, the efficacy of metronomic chemotherapy seems to increase when administered in combination with specific antiangiogenic
Keywords - Anti-angiogenesis, Cancer, Chemotherapy, Metronomic.