Paper Title
Synthesis and Bio-Activitystudies Schiff Bases Derived from 1-(2-Salicylaldiminoethyl) Piperazines

The Schiff base derivatives of 1-(2-salicylaldiminoethyl)piperazines were synthesized, characterized and evaluated for their biological activity on human acetylcholinesterase (hAChE), antioxidant and molecular dockingproperties. The study demonstrated that the compound 4-methoxy-2-((2-(piperazin-1-yl)ethylimino)methyl)phenol (LHM) has the highest activity in all the assays. The hAChE inhibitory activities of LHM is comparable with the standard used.However,LHM could not be considered as abivalent ligand due to its inability to occupy theesteractic site(ES)region. This activity can be attributed to its capability in blocking the active gorge thereby preventing the substrate and acetylcholine from entering the active site. The antioxidant studies revealed variable results for the DPPH and FRAP assays which indicates disparity in the mechanism at which the compounds responds in the two assays. Keywords- Antioxidant, hAChE inhibition, Molecular docking,Characterizations,Synthesis.