Efficiency of Folate-Decorated Methotrexate Nanoparticles in MCF-7
This study aim to prepare targeted nanoparticles from tri and di-block copolymer of PEGylatedP(CL) and
investigate in vitro study in MCF-7. MTX conjugated copolymers at 10% and subsequently decorated with FOL-conjugated
copolymers at 5 were prepared from PCL-PEG-PCL (tri-block pattern) and mPEG-PCL (di block pattern) via click reaction.
After that, non-targeted and targeted nanoparticle were prepared by dialysis method. Four type of nanoparticles were
investigated their characteristics and cytotoxicity. The results found that the targeted nanoparticles were toxic to MCF-7 than
non-targeted nanoparticles. Moreover, targeted nanoparticles form tri-block pattern were effective than di-block
nanoparticles due to the different formation of nanoparticles.
Keywords - Targeted nanoparticles, methotrexate, folic acid, MCF-7