Paper Title :Pharmacological Evaluation of 2-(Phenyl Hydrazino Methyl) Quinazolin-4(3h)-One for Anticancer Activity Focussed on Anti-Parp Activity
Author :Anchitha Teresa George, Winson Sam
Article Citation :Anchitha Teresa George ,Winson Sam ,
(2018 ) " Pharmacological Evaluation of 2-(Phenyl Hydrazino Methyl) Quinazolin-4(3h)-One for Anticancer Activity Focussed on Anti-Parp Activity " ,
International Journal of Advances in Science, Engineering and Technology(IJASEAT) ,
pp. 43-49,
Volume-6, Issue-4
Abstract : Poly (ADP-ribosyl) polymerases (PARPs) are enzymes that catalyze the synthesis of the biopolymer Poly (ADPribose)
(PAR), a post translational modification that plays an important role in genomic repair, gene transcription, energy
metabolism, cell signalling etc.2-(phenyl hydrazino methyl) quinazolin-4(3H)-one, being NAD+ mimetics can act as PARP
inhibitors, hence can be used as an anticancer drug. The compound is evaluated for its antiPARP activity and it showed
significant anticancer property.
Keywords - PARP, ARTD,PARsylation,NAD+, BRCA mutations, 4(3H)-Quinazolinone,SAR,PASSonline,2-(phenyl
hydrazino methyl) quinazolin-4(3H)-one, antiPARP activity. In silico, docking
Type : Research paper
Published : Volume-6, Issue-4
DOIONLINE NO - IJASEAT-IRAJ-DOIONLINE-13933
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Copyright: © Institute of Research and Journals
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Published on 2018-12-26 |
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